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研究内皮素－１（ＥＴ－１）在猫延髓头侧腹外侧区（ｒＶＬＭ）对心血管活动的影响．方法：采用脑立体定向和脑内微量注射技术．结果：ｒＶＬＭ内微量注射 ＥＴ－１（４μｍｏｌ·Ｌ－１， ０．５μＬ）后，平均动脉压（ＭＡＰ）升高（３．７±１．３）ｋＰａ，心率增加（２９±７）ｂｅａｔｓ·ｍｉｎ－１，肾神经活动增加 ４５％±１０％，量－效呈正相关．双颈部迷走神经切断后不影响上述结果．静脉预先给予酚妥拉明 ５ ｍｇ·ｋｇ－１能显著抑制ＥＴ－１的升压作用．血浆精氨酸升压素（Ａｒｇ）含量由（１２．４± ６． ５） ｎｇ· Ｌ－１增加到（７０．３± ２４． ２）ｎｇ·Ｌ－１，并与ＭＡＰ变化显著相关，使缺血心脏心律紊乱（ＨＲｈＤ），ＨＲｈＤ出现在结扎后（４．８±２．９）ｍｉｎ，评分为 ４．４±１．６，与对照组差异显著．结论：ｒＶＬＭ内注射ＥＴ－１影响了心血管和交感神经活动的中枢调节。
To investigate the effect of endothelin-1 (ET-1) on cardiovascular activity in the rostral ventrolateral medulla (rVLM). Methods: Brain stereotactic and intracerebral microinjection techniques were used. RESULTS: Mean arterial pressure (MAP) increased (3.7 ± 1.3) kPa and heart rate increased (29 ± 7)% after microinjection of ET-1 (4μmol·L-1, 0.5μL) into rVLM min-1, renal nerve activity increased by 45% ± 10%, the amount of - effect was positively correlated. Two-neck vagus nerve cut off does not affect the above results. Pretreatment of intravenous phentolamine 5 mg · kg-1 significantly inhibited the ET-1 vasopressor effect. The content of Arginine in plasma increased from (12.4 ± 6.5) ng · L-1 to (70.3 ± 2. 2) ng · L-1, and was significantly correlated with the change of MAP. The HRhD and HRhD were significantly higher than those of the control group (4.8 ± 2.9) min after the ligation, with a score of 4.4 ± 1.6. Conclusions: Intravenous injection of ET-1 into rVLM affects central regulation of cardiovascular and sympathetic activity.