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关于钙通道阻滞剂(calcium-channel blocker,CCB)预防和治疗肝纤维化的研究,国外仅见Cutrin报道了硝苯吡啶对大鼠实验性肝纤维化的初步作用,国内通过实验与临床研究,发现CCB在减轻肝脏炎症与肝细胞损伤、干扰细胞外基质产生并增加其分解、抑制储脂细胞增殖与转化及抑制成纤维细胞DNA与蛋白质合成等方面具有较好的作用,本文就此作一综述。 1 对血清PⅢP及PCⅢ的影响 血清PⅢP来源于Ⅲ型前胶原,在胶原合成旺盛时,血清PⅢP含量升高,是目前研究最多的反映肝纤维化的指标。多数研究表明,血清PⅢP能较好地反映肝纤维组织生成的
On the calcium channel blocker (calcium-channel blocker, CCB) in the prevention and treatment of liver fibrosis, Cutrin reported only the preliminary effect of nifedipine on experimental hepatic fibrosis in rats abroad, through experimental and clinical studies, It is found that CCB plays a good role in alleviating hepatic inflammation and hepatocellular injury, interfering with extracellular matrix production and increasing its decomposition, inhibiting the proliferation and transformation of lipid-storing cells and inhibiting DNA and protein synthesis of fibroblasts, and so on. . 1 on the serum P Ⅲ P and PC Ⅲ serum P Ⅲ P derived from type Ⅲ procollagen in the synthesis of strong collagen, serum P Ⅲ P content, is currently the most studied indicators of liver fibrosis. Most studies have shown that serum P Ⅲ P can better reflect the formation of liver fibrosis