宿主对细菌感染的天然应答主要是由中性粒细胞和单核-巨噬细胞介导的炎症反应,从而促进感染性因子的清除及组织修复;过度的炎症反应则可导致组织损伤及脓毒性休克。本文作者提出该炎症反应可因TREM-1介导的通路放大。 TREM-1是新近鉴定的一种表达于人中性粒细胞和单核细胞的受体,属于免疫球蛋白超家族。它可以通过一种相关的信号转导分子DAP12促进细胞活化,并且可以引起促炎症介质的分泌。作者在体外利用流式细胞仪检测了分别与热灭活的革兰阳 The host’s natural response to bacterial infection is mainly mediated by neutrophils and monocytes - macrophages, which promotes the clearance of infectious agents and tissue repair. Excessive inflammation can lead to tissue damage and sepsis shock. The authors propose that this inflammatory response may be amplified by the TREM-1-mediated pathway. TREM-1 is a recently identified receptor expressed on human neutrophils and monocytes, belonging to the immunoglobulin superfamily. It promotes cell activation through an associated signaling molecule, DAP12, and can elicit the secretion of proinflammatory mediators. The authors tested the in vitro use of flow cytometry with heat-inactivated Gram-positive