组织因子(TF),以前称为thromboplastin是启动凝血级联反应的关键性因子。它与VIIa结合,激活Ⅸ、X因子,最后形成纤维蛋白。多种细胞因子、生长因子和生物生成的胺等多种刺激使内皮细胞、血管平滑肌细胞和单核细胞表达及活化TF。这些介质通过各种不同的信号转导机制(包括多种MAP Tissue factor (TF), formerly known as thromboplastin, is a key factor in initiating the coagulation cascade. It binds to Vila, activates IX, X, and finally forms fibrin. A variety of cytokines, growth factors and bio-generated amines and many other stimuli of endothelial cells, vascular smooth muscle cells and monocytes express and activate TF. These mediators work through a variety of different signaling mechanisms (including multiple MAPs