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目的观察血管紧张素转换酶(ACE)和醛固酮在房颤导管消融术前、后的变化,探讨其在预测房颤复发的应用价值。方法选择经导管消融术的持续性房颤患者(房颤组)38例,同期选择窦性心律患者38例作为对照组,收集房颤组术前、后,对照组入院第2d血清,测定血清ACE和醛固酮浓度。结果房颤组血清ACE和醛固酮浓度显著高于对照组,经过导管消融术后血清ACE和醛固酮浓度均显著下降,差异有统计学意义(P>0.05)。结论 ACE和醛固酮浓度对于房颤的诊断与评估及在预测导管消融后房颤复发方面有重要的应用价值。
Objective To observe the changes of angiotensin converting enzyme (ACE) and aldosterone before and after the catheter ablation of atrial fibrillation (AF), and to explore its value in predicting recurrence of atrial fibrillation. Methods Thirty-eight patients with persistent AF (atrial fibrillation group) undergoing catheter ablation and 38 patients with sinus rhythm over the same period were selected as the control group. Serum was collected before and after admission ACE and aldosterone concentrations. Results Serum ACE and aldosterone concentrations in AF group were significantly higher than those in control group. The serum ACE and aldosterone concentrations were significantly decreased after catheter ablation (P> 0.05). Conclusions The diagnostic value of ACE and aldosterone in the diagnosis of atrial fibrillation and the prediction of recurrence of atrial fibrillation after catheter ablation have important value.