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目的考察香丹注射液与3种代糖溶媒(果糖注射液、转化糖注射液和转化糖电解质注射液)配伍的稳定性,为糖尿病患者的临床用药提供参考。方法按临床用药的最大使用量,制备香丹注射液与3种代糖溶媒的配伍溶液,考察配伍溶液的外观、p H值、不溶性微粒、含量测定、紫外光谱及最大吸收波长。结果其中一批香丹注射液与转化糖电解质注射液配伍20 min后出现浑浊,其他溶液在5 h内,溶液性状、不溶性微粒、含量、紫外光谱及最大吸收波长均无显著变化,p H值在正常范围内略有变化。结论不建议香丹注射液与转化糖电解质注射液临床配伍使用,其他溶液在配伍5 h内基本稳定,建议配伍静置一段时间后再输注,以提高输液的安全性。
Objective To investigate the stability of compatibility of Xiangdan injection with three kinds of sugar substitute vehicles (fructose injection, invert sugar injection and transfusion sugar electrolyte injection), and to provide a reference for the clinical use of drug in patients with diabetes mellitus. Methods According to the maximum dosage of clinical medication, the compatibility solution of Xiangdan injection with three kinds of glucose substitute solvent was prepared. The appearance, p H value, insoluble particles, content of UV, and the maximum absorption wavelength were investigated. Results One batch of Xiangdan injection showed turbidity after 20 min compatibility with invert sugar electrolyte solution. The other solutions showed no significant change in solution properties, insoluble particles, content, UV spectrum and maximum absorption wavelength within 5 h. The values of p H Within the normal range of slight changes. Conclusion It is not recommended that Xiangdan Injection and Transforming Sugar Electrolyte Injection should be used in clinical compatibility. Other solutions should be stable within 5 hours after compatibility. It is suggested that the compatibility be allowed to stand for a period of time before infusion to improve the safety of infusion.