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对一组连续入院自愿戒毒的海洛因依赖者用丁丙诺啡加纳洛酮与阿片酊治疗效果的比较研究。将依赖者按照性别、年龄、职业、用毒史、日用毒量、用毒途径等条件归入丁丙诺啡加纳洛酮治疗组或阿片酊治疗组。采用“阿片类药物戒断反应量表”，由患者每日自行评定戒断反应，作为疗效主要评定项目；隔日作尿液吗啡定性检测。两组治疗在用药程式、用药外观上完全相同，患者对所用药物不知。发现：１．丁丙诺啡加纳洛酮能够有效的控制海洛因戒断反应，总体疗效优于阿片酊，２．丁丙诺啡加纳洛酮治疗方法临床上病人是可接受的，病人的依从性佳，３．丁丙诺啡加纳络酮能够使患者机体处于接受阿片受体拮抗剂的状态，从而为纳屈酮维持治疗创造了条件。４．此外还发现，海洛因日用毒量大和病史长者，躯体戒断反应重；无固定职业者、注射者、年龄大者渴求明显；单纯药物治疗、自愿治疗很难真正使海洛因依赖者保持戒毒状态。
Comparative study of the efficacy of buprenorphine plus ganadol and opium tinctures in a group of heroin dependent patients who were admitted to hospital voluntarily. The dependent persons were classified into buprenorphine plus naloxone group or opiate tincture group according to the sex, age, occupation, drug history, daily virulence, and the route of drug use. Using “opiate withdrawal response scale” by the patient daily assessment of withdrawal response, as the main evaluation of the efficacy of the project; the other day for the qualitative detection of morphine in urine. Treatment of two groups in the medication program, medication appearance exactly the same, patients do not know the drugs used. Found: 1. Buprenorphine plus ganaloxone can effectively control the heroin withdrawal response, the overall effect is superior to opium tincture, 2. Buprenorphine Garconidone treatment is clinically acceptable in patients with good patient compliance, 3. Buprenorphine Garonetine Ketone allows the patient’s body to be in the state of opioid receptor antagonists, thus creating the conditions for naltrexone maintenance. 4. In addition, it was also found that the daily dose of heroin and the history of the elderly were high, and the body was severely withdrawn from the body. In the case of the unemployed, the injecting person and the elderly were desperate for obvious symptoms, drug treatment and voluntary treatment were very difficult to truly detoxify the heroin addicts .