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分析先兆流产患者妊娠结局与外周血CD4~+CD25~+Foxp3~+调节性T细胞的联系。对先兆流产患者采用黄体酮针40mg im qd,HCG针2000 u im qod,地屈孕酮片1片Bid po,维生素E丸1粒Tid po的治疗方案保胎;采用细胞内染色流式细胞术,分析外周血CD4~+CD25~+Foxp3~+T细胞亚群。结果:28例先兆流产患者经用以上治疗方案保胎后,18例成功,10例失败。经治疗后,保胎成功组外周CD4~+CD25~+Foxp3~+/CD4~+、CD4~+Foxp3~+、CD25~+Foxp3~+T细胞比例显著高于保胎失败组(P<0.05),并显著高于保胎治疗前(P<0.05)。外周调节性T细胞升调节有利于成功妊娠。
Analysis of the relationship between pregnancy outcomes and CD4 ~ + CD25 ~ + Foxp3 ~ + regulatory T cells in peripheral blood in patients with threatened abortion. In patients with threatened abortion, we adopted the treatment regimen of 40 mg im qd of progesterone needle, 2000 u im qod of HCG needle, 1 bid po of dextromethorphan tablet and 1 Tid po of vitamin E pill; , Analysis of peripheral blood CD4 ~ + CD25 ~ + Foxp3 ~ + T cell subsets. Results: Twenty-eight cases of threatened abortion were successfully treated with the above treatment plan and 10 cases failed. After treatment, the proportion of CD4 ~ + CD25 ~ + Foxp3 ~ + / CD4 ~ +, CD4 ~ + Foxp3 ~ + and CD25 ~ + Foxp3 ~ + T cells in the failed fetus group was significantly higher than that of the failed fetus failed group ), Which was significantly higher than that before tocolysis (P <0.05). Peripheral regulatory T cell upregulation contributes to successful pregnancy.