妊娠相关蛋白-A(PAPP-A)是金属蛋白锌家族中的一员,最初在妊娠妇女的血浆中发现。用于婴儿唐氏综合征的诊断。近来发现PAPP-A也存在于非孕妇的非胎盘组织,在男性体内亦存在。外周血PAPP-A浓度最近已被推荐作为急性冠脉综合征的生物学标记物。高血压病患者PAPP-A浓度显著偏高。PAPP-A可能通过胰岛素样生长因子(IGF)影响心血管系统。 Pregnancy-associated protein-A (PAPP-A), a member of the metalloproteinoprotein family, was first found in the plasma of pregnant women. For the diagnosis of infant Down Syndrome. PAPP-A has recently been found in non-pregnant non-placental tissues, which are also present in males. Peripheral blood PAPP-A concentrations have recently been proposed as biomarkers of acute coronary syndrome. PAPP-A concentrations were significantly higher in hypertensive patients. PAPP-A may affect the cardiovascular system through insulin-like growth factor (IGF).