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本文报告了临床及实验研究两方面的结果。以益气健脾、清热解毒中药治疗消化性溃疡及糜烂性胃炎患者６２例，并观察治疗前后胃粘膜ＰＧｓ的动态变化。结果显示经治疗后ＰＧＥ２，ＰＧＦ１ａ，６－ｋｅｔｏ—ＰＧＦ１ａ呈上升趋势，但无统计学意义（Ｐ＞０．０５），而ＴｘＢ２较治疗前显著下降（Ｐ＜０．０１）。此外，还观察到治疗前的湿热型患者的ＴｘＢ２比其他证型患者高（Ｐ＜０．０１）。将上述中药用于吲哚美辛诱发的大鼠实验性溃疡，其结果表明，对ＰＧｓ的影响与临床观察一致。
This article reports results from both clinical and experimental studies. Treating 62 patients with peptic ulcer and erosive gastritis with Qi-invigorating, spleen-clearing, heat-clearing and detoxicating herbs, and observe the dynamic changes of gastric mucosal PGs before and after treatment. The results showed that after treatment, PGE2, PGF1a, 6-keto-PGF1a showed an upward trend, but no statistical significance (P> 0.05), but TxB2 decreased significantly compared with before treatment (P <0.01). In addition, it was also observed that TxB2 was higher in pre-treatment damp-heat patients than in other patients (P<0.01). The above-mentioned Chinese medicine was used for experimental ulcers induced by indomethacin in rats. The results showed that the effects on PGs were consistent with clinical observations.