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目的：观察狼疮性肾炎（ＬＮ）患者肾组织中单核细胞趋化因子（ＭＣＰ－１）的分布与肾小管间质病变的关系，分析其与患者蛋白尿及肾间质单核细胞浸润之间的联系，探讨其在ＬＮ患者肾小管间质病变发生中的作用。方法：１８例经肾活检确诊的ＬＮ患者，肾间质ＭＣＰ－１及ＣＤ６８＋浸润细胞检测采用ＰＡＰ四层法进行免疫组化染色，分析肾间质ＭＣＰ－１的分布与患者蛋白尿程度，间质ＣＤ６８＋细胞浸润以及肾小管间质损伤程度的关系。结果：１８例患者肾组织中ＭＣＰ－１主要位于肾小管及间质小血管壁。肾小管ＭＣＰ－１的表达与患者尿蛋白程度无相关性，但与间质ＣＤ６８＋细胞浸润数及肾间质病变的程度明显相关。结论：ＬＮ患者肾小管ＭＣＰ－１表达增加，是导致间质单核细胞浸润及肾小管间质损伤的一个重要原因。
Objective: To investigate the relationship between the distribution of monocyte chemotactic factor (MCP-1) and tubulointerstitial lesions in renal tissue of patients with lupus nephritis (LN), and to analyze the relationship between MCP-1 and tubulointerstitial lesions in patients with proteinuria and interstitial mononuclear cell infiltration Between the relationship between LN in patients with tubulointerstitial lesions in the role. Methods: 18 cases of LN patients confirmed by renal biopsy were examined by immunohistochemical staining of MCP-1 and CD68 + in adrenal interstitial cells. The distribution of MCP-1 in renal interstitium and the level of proteinuria were analyzed. CD68 + cell infiltration and the degree of tubulointerstitial injury. Results: MCP-1 in renal tissue of 18 patients was mainly located in the small blood vessels of the tubules and the stroma. The expression of tubular MCP-1 had no correlation with the degree of urinary protein in patients, but it was significantly correlated with the number of interstitial CD68 + cells and the degree of renal interstitial lesions. CONCLUSION: Increased expression of MCP-1 in the renal tubules of LN patients is an important cause of interstitial mononuclear cell infiltration and tubulointerstitial injury.