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定向地设计作用于特定受体的维甲配体分子对于阐明维甲作用的分子机制、合成新作用类型的维甲类化合物有重要意义。本文在研究系列维甲Ｘ受体特异性配体的二维与三维构效关系的基础上，考察了维甲Ｘ核受体对其配体的结构及电性需求，以进一步指导设计和合成特异性的维甲Ｘ受体激动剂。
Directing the design of retinal ligand molecules acting on specific receptors is of great importance for the elucidation of the molecular mechanism of retinal action and the synthesis of a new type of retinoid. Based on the study of the relationship between the two-dimensional and three-dimensional structure-activity relationship of a series of retinoic acid X receptor-specific ligands, the structure and electrical requirements of the ligands of the vimentin X nuclear receptor were investigated to further guide the design and synthesis Specific retinoid X receptor agonist.