作者在大鼠回肠袢模型中比较了三种配方的口服霍乱菌苗的免疫原性和保护性。作者选用8周龄Wistar大鼠为实验动物,随机分为5组,第1组给予口服菌苗A 3次,每次间隔14天,此菌苗由包被霍乱弧菌脂多糖(LPS)、菌毛(F)和前类霍乱原(P)的脂质体组成;第2组和第3组按相同免疫程序分别给予口服菌苗B和C,这两种菌苗分别由经加热灭活的有菌毛和无菌毛霍乱弧菌全菌体 The authors compared the immunogenicity and protection of three formulations of oral cholera vaccine in a rat ileocecal model. The authors selected 8-week-old Wistar rats as experimental animals, were randomly divided into five groups, the first group was given oral vaccine A 3 times, each interval of 14 days, the vaccine consists of Vibrio cholerae lipopolysaccharide (LPS) (F) and pre-cholera (P) liposomes; Groups 2 and 3 were administered oral vaccine B and C, respectively, under the same immunization schedule, both of which were separately inactivated by heat Pseudomonas and asexual Vibrio cholerae whole bacteria