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作者对50名未选择的真性红细胞增多症(真红)病例,应用生化方法测定血红蛋白F含量,并应用抗HbF抗体荧光法测定F细胞。发现真红病例末梢血F细胞比率大部分在正常对照范围之内,但有1/4病例其HbF含量和F细胞显著增高。其中有5例30～45%红细胞含有胎儿血红蛋白。此5例中每个F细胞含有HbF为14.8%(由F细胞的比例和溶血液中HbF含量计算)。2例F细胞增高的病例测定HbF中Ar和Gr链成分,其氨基酸残基为0.3和0.5,与成人HbF所见者相一致。未发现F细胞水平与红细胞压积、病期或治疗方式有何关系。7例发生骨髓纤维化,其中1例F细
The author of 50 unselected polycythemia vera (true red) cases, the application of biochemical methods for determination of hemoglobin F content, and the use of anti-HbF antibody fluorescence determination of F cells. Found that true red cases of peripheral blood F cells in most of the normal control range, but 1/4 cases of HbF content and F cells were significantly higher. Among them, 5 cases of 30 to 45% erythrocytes contain fetal hemoglobin. Each of these 5 F cells contains 14.8% HbF (calculated from the F cell ratio and the HbF content in the hemolysis). Two cases of elevated F cells were assayed for Ar and Gr chain components in HbF with amino acid residues of 0.3 and 0.5, consistent with those seen in adult HbF. No correlation was found between F-cell levels and hematocrit, disease duration, or treatment. 7 cases of bone marrow fibrosis, including 1 case of F fine