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经前紧张综合征(PMS)严重影响生活质量。有足够的证据显示卵巢功能与PMS有关。促性腺激素释放激素类药物(GnRH-a)对排卵的抑制作用可导致医源性的可逆性绝经,结果PMS症状减轻。本实验是对中～重度PMS妇女应用GnRh-a加激素补充疗法,超过12个月的长期治疗的有效性和安全性的研究。
Premenstrual tension syndrome (PMS) seriously affects the quality of life. There is sufficient evidence that ovarian function is related to PMS. Inhibition of ovulation by gonadotropin-releasing hormone drugs (GnRH-a) leads to iatrogenic reversible menopause, resulting in reduction of PMS symptoms. This is a study of the efficacy and safety of long-term treatment over 12 months of GnRh-a plus hormone replacement therapy in women with moderate-to-severe PMS.