在美国,FDA批准的治疗皮肤癣菌所致指甲真菌病的两种药物是伊曲康唑和特比萘芬。伊曲康唑和特比萘芬分别在不同的位点抑制真菌细胞膜麦角甾醇的合成。联合使用这两种药物具有优越性。为了评价伊曲康唑和特比萘芬连续冲击治疗指甲真菌病的疗效和安全性,作者进行了一项开放的、前瞻性的、多中心的、非药商赞助的研究。 In the United States, the two drugs approved by the FDA for treating nail fungal diseases caused by dermatophytes are itraconazole and terbinafine. Itraconazole and terbinafine inhibit fungal cell membrane ergosterol synthesis at different sites, respectively. The combination of these two drugs has the advantage. In order to evaluate the efficacy and safety of itraconazole and terbinafine in the continuous impact treatment of nail fungal diseases, the authors conducted an open, prospective, multicenter, non-pharmacokinetic study.