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目的研究转录因子FOXL2在正常宫颈组织及宫颈癌组织中的表达,探讨其在宫颈癌中的临床意义。方法免疫组化法检测10例正常宫颈和18例宫颈癌组织(10例Ⅰ期,8例Ⅱ+Ⅲ期)中FOXL2的表达情况,分析比较其表达与临床特征的关系。结果 FOXL2在正常宫颈组织中表达为0,在18例宫颈癌组织FOXL2阳性表达率为72.2%(13/18),其中宫颈癌I期阳性表达率50%,Ⅱ期及Ⅲ期阳性表达率为100%。FOXL2表达与宫颈癌临床分期、病理分级相关(P<0.05),而与宫颈癌患者的年龄无明显相关(P>0.05)。结论 FOXL2表达水平与宫颈癌恶性度呈正相关,且随着宫颈病变进展,FOXL2的阳性表达率呈递增趋势。
Objective To study the expression of FOXL2 in normal cervical tissue and cervical cancer and to explore its clinical significance in cervical cancer. Methods The expression of FOXL2 in 10 cases of normal cervix and 18 cases of cervical cancer (10 cases in stage Ⅰ, 8 cases in stage Ⅱ + Ⅲ) was detected by immunohistochemistry. The relationship between the expression of FOXL2 and clinical features was analyzed. Results The expression of FOXL2 in normal cervical tissue was 0, and the positive rate of FOXL2 in 18 cases of cervical cancer was 72.2% (13/18). The positive expression rate of FOXL2 in cervical cancer was 50%, the positive expression rate in stage Ⅱ and Ⅲ was 100%. FOXL2 expression was correlated with clinical stage and pathological grade of cervical cancer (P <0.05), but not with the age of cervical cancer (P> 0.05). Conclusion The expression of FOXL2 is positively correlated with the malignant degree of cervical cancer. With the progression of cervical lesions, the positive rate of FOXL2 is increasing.