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为了证实注射油酸是否能诱导出一个稳定、可复制的急性肺损伤模型,作者对5头约克郡猪于麻醉后做气管切开,呼吸机通气。在注射油酸前、注射期和注射后4小时连续测定以下指标:体循环平均动脉压(MAP)、平均肺动脉压(MPAP)、混合静脉血氧饱和度(S(?)O_2)、动脉血氧饱和度(SaO_2)、每分钟氧耗量((?)O_2)和心率(HR)。IBM/pc计算机根据上述数据每20秒给出1次死腔比率(V_T/V_D)、静脉血掺杂率(Qsp/(?)t)、肺循环阻力(PVR)、体循环率力(SVR)和心输出量((?)t)的结果,每头猪注射油酸0.08ml/kg,注射时间在30分钟以上。结果表明,注射油酸中的第10分钟,心肺参数基本无变化,其后15分钟PVR(61%)、HR(14%)MPAP(52%)、(?)sp/(?)t(250%)和V_D/V_T
To confirm whether injection of oleic acid induces a stable, replicable model of acute lung injury, the authors tracheotomized 5 Yorkshire tracts after anesthesia and ventilated the ventilator. The indexes of arterial pressure (MAP), mean pulmonary arterial pressure (MPAP), mixed venous oxygen saturation (S (?) O_2), arterial oxygen Saturation (SaO_2), oxygen consumption per minute (O 2) and heart rate (HR). The IBM / pc computer gave a dead space ratio (V_T / V_D), venous blood doping rate (Qsp / (t)), pulmonary resistance (PVR) and systemic circulation rate (SVR) Cardiac output ((?) T) results, each pig injection of oleic acid 0.08ml / kg, injection time of more than 30 minutes. The results showed that there was almost no change in cardiopulmonary parameters at 10 minutes after injection of oleic acid. PVR (61%), HR (14%) MPAP (52%), %) And V_D / V_T