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目的:探讨姜黄素对不稳定型心绞痛患者血清明胶酶水平的影响。方法:选择2010年1月至2010年9月住院的不稳定型心绞痛患者共80例,随机分为常规治疗对照组(n=40)和姜黄素治疗组(n=40),分别测定两组治疗前及治疗30d后血清明胶酶[包括基质金属蛋白酶-2(MMP-2)和MMP-9]的水平。结果:与治疗前比较,姜黄素治疗组治疗后血清明胶酶水平明显下降[MMP-2:(52.64±6.77)ng/ml:(32.65±1.67)ng/ml,MMP-9:(56.75±7.34)ng/ml:(35±1.88)ng/ml],P<0.01。姜黄素治疗组治疗后血清明胶酶水平明显低于常规治疗对照组治疗后[MMP-2:(32.65±1.67)ng/ml:(37.78±2.76)ng/ml,MMP-9:(35±1.88)ng/ml:(40.23±1.95)ng/ml],P<0.05。结论:姜黄素能降低不稳定型心绞痛患者血清明胶酶水平,起到稳定粥样斑块的作用。
Objective: To investigate the effect of curcumin on serum gelatinase in patients with unstable angina pectoris. Methods: A total of 80 unstable angina patients hospitalized from January 2010 to September 2010 were randomly divided into routine treatment control group (n = 40) and curcumin treatment group (n = 40), and were divided into two groups Serum gelatinases [including matrix metalloproteinase-2 (MMP-2) and MMP-9] were measured before and 30 days after treatment. Results: Compared with those before treatment, serum levels of gelatinase in curcumin treatment group were significantly decreased [(52.64 ± 6.77) ng / ml vs (32.65 ± 1.67) ng / ml, MMP-9: (56.75 ± 7.34 ) ng / ml: (35 ± 1.88) ng / ml], P <0.01. The level of serum gelatinase in curcumin treatment group was significantly lower than that in the control group after treatment [MMP-2: (32.65 ± 1.67) ng / ml: 37.78 ± 2.76 ng / ml, MMP-9: ) ng / ml: (40.23 ± 1.95) ng / ml], P <0.05. Conclusion: Curcumin can reduce the level of serum gelatinase in patients with unstable angina and play the role of stabilizing atherosclerotic plaque.