论文部分内容阅读
1968年,Prien等首先观察到痛风病人经常自尿中排出草酸钙成分的结石,但这些病人并没有钙代谢方面的异常。而后,一些学者先后发现,相当多的草酸钙结石病人尿中排出的尿酸量明显高于正常人。这些病人在临床上可以没有痛风的症状,在应用抗嘌呤代谢药物使病人尿酸排出降到正常水平后,就会显著地减少新结石的发生。这些情况提示高尿酸尿与草酸钙结石形成之间可能存在着内在联系。随着认识的深入,近年Coe及Pak将这一症候群命名为“高尿酸尿性草酸钙肾石病”(hyperuricosuric calcium oxalate nephrolithiasis)。本文就这一综合
In 1968, Prien et al. First observed that gout patients often discharge stones of calcium oxalate composition from the urine, but these patients did not have any abnormal calcium metabolism. Later, some scholars have found that a considerable number of calcium oxalate stones urinary excretion of urine was significantly higher than normal. These patients can be clinically gout-free symptoms, the use of anti-purine metabolism of drugs in patients with uric acid excretion to normal levels, it will significantly reduce the occurrence of new stones. These conditions suggest that there may be an intrinsic link between high uric acid urolithiasis and formation of calcium oxalate stones. With the deepening of understanding, in recent years, Coe and Pak named the syndrome “hyperuricosuric calcium oxalate nephrolithiasis.” This article on this synthesis