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Several studies investigated associations of IFN-γ rs2430561 T/A,IL28 B rs12979860 C/T and ERα rs2077647 T/C gene polymorphisms with outcomes of hepatitis B virus(HBV) infection,but the results were controversial.Therefore,we performed a meta-analysis of all published observational studies to address this inconsistency.Literature was searched in online database and a systematic review was conducted based on the search results.A total of 24 studies were included and dichotomous data were presented as odds ratio(OR) with a 95%confidence interval(CI).The rs2430561 T allele was associated with reduced persistent HBV infection risk(T vs.A:OR,0.690;95%CI,[0.490,0.971]),while the rs2077647 T allele significantly increased the risk of persistent HBV infection(T vs.C:OR.1.678;95%CI,[1.212,2.3231).Rs 2077647 CC might play a role in protecting individuals against HBV persistence(TT vs.CC:OR,4.109;95%CI,[2.609,6.473]).Furthermore,carriers of the rs2430561 TT genotype were more likely to clear HBV spontaneously compared with those of the AA genotype(TT vs.AA:OR,0.555;95%CI,[0.359,0.856]).For rs12979860 C/T polymorphism,no significant correlation with HBV infection outcomes was found.In subgroup analyses,the results were similar to those of overall analysis.However,for rs2077647 TT vs.TC+CC,significantly increased risks were observed in the Asian and hospital-based population,but not in the overall analysis.IFN-γrs2430561 T/A and ERα rs2077647 T/C genetic polymorphisms were associated with outcomes of HBV infection,but no association was found between IL28 B rs12979860 C/T and HBV infection.
Several studies assign associations of IFN-γ rs2430561 T / A, IL28 B rs12979860 C / T and ERα rs2077647 T / C gene polymorphisms with outcomes of hepatitis B virus (HBV) infection, but the results were controversial. Beforefore, we performed a meta -analysis of all published observational studies to address this inconsistency. Literature was searched in online database and a systematic review of conducted on the search results. A total of 24 studies were included and dichotomous data were presented as odds ratio (OR) with a 95% confidence interval (CI). The rs2430561 T allele was associated with reduced persistent HBV infection risk (T vs. A: OR, 0.690; 95% CI, [0.490,0.971]), while the rs2077647 T allele significantly increased the risk of persistent HBV infection (T vs. C: OR.1.678; 95% CI, [1.212, 2.3231] .Rs 2077647 CC might play a role in protecting individuals against HBV persistence (TT vs. CC: OR, 4.109; 95% CI , [2.609, 6.473]). Furthermore, carriers of the rs2430561 TT genotype were more likely to clear HB V spontaneously compared with those of the AA genotype (TT vs. AA: OR, 0.555; 95% CI, [0.359,0.856]). For rs12979860 C / T polymorphism, no significant correlation with HBV infection outcomes was found.In subgroup analyzes , the results were similar to those of overall analysis. Although, for rs2077647 TT vs. TC + CC, significantly increased risks were observed in the Asian and hospital-based population, but not in the overall analysis. IFN-γ rs2430561 T / A and ERα rs2077647 T / C genetic polymorphisms were associated with outcomes of HBV infection, but no association was found between IL28 B rs12979860 C / T and HBV infection.