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目的:比较不同剂量沙利度胺片治疗复发性阿弗它溃疡的临床效果和不良反应。方法:复发性口腔溃疡90例随机分为3组,第1组沙利度胺片低剂量(25mg/次,tid)加六味地黄丸;第2组沙利度胺片低剂量(25mg/次,tid)。第3组沙利度胺片常规剂量(50mg/次,bid)。观察研究治疗前后血小板聚集和血液流变性、总间歇时间和总溃疡数评价指标的变化。结果:治疗效果第1组(34例)和第3组(23)例优于第2组(33例)(P<0.05);第3组疗效与第1组差异无显著性,不良反应(嗜睡、乏力)高于第1组和第2组(P<0.05)。第1组痊愈率、显效率、有效率、总有效率为79.4%、8.8%、5.9%、94.1%,第2组为54.5%、12.1%、15.2%、81.8%,第3组为73.9%、13.0%、8.6%、95.6%。结论:复发性阿弗它溃疡可能是多因素类疾病,低剂量沙利度胺片联合六味地黄丸治疗复发性阿弗它溃疡能迅速控制症状,减少复发,临床疗效有效确切,并且有很好的应用前景。
OBJECTIVE: To compare the clinical effects and adverse reactions of thalidomide tablets in the treatment of recurrent aphthous ulcer. Methods: 90 cases of recurrent oral ulcer were randomly divided into 3 groups: group 1 thalidomide low dose (25mg / tid) plus Liuweidihuangwan; group 2 thalidomide low dose (25mg / time , tid). Group 3 thalidomide conventional dose (50mg / time, bid). Observed before and after treatment platelet aggregation and blood rheology, the total intermittent time and the total number of ulcer evaluation index changes. Results: The first group (34 cases) and the third group (23 cases) had better curative effect than the second group (33 cases) (P <0.05), the third group had no significant difference with the first group Drowsiness, fatigue) were higher than the first group and the second group (P <0.05). The total effective rate of Group 1 was 79.4%, 8.8%, 5.9%, 94.1%, 54.5%, 12.1%, 15.2%, 81.8% in Group 2, 73.9% in Group 3, , 13.0%, 8.6%, 95.6%. Conclusions: Recurrent aphthous ulcer may be a multifactorial disease. Low-dose thalidomide combined with Liuweidihuangwan can cure recurrent aphthous ulcer and control the symptoms quickly and reduce recurrence. The clinical curative effect is effective and exact, and it is very good The application prospects.