采用金葡球菌和大肠杆菌混合感染，及淋球菌感染两种阴道炎模型，以阴道充血、水肿、出血为指标，观察细菌对粘膜损伤程度。对复方环丙沙星栓（ＣＣＩＰＳ）的三个剂量组的治疗效果进行考察，结果表明，在两个模型组给药实验中，该药物高剂量组与阳性对照组有显著性差异，同时进行了阴道粘膜刺激性实验、急性毒性实验，表明该药物对大鼠阴道粘膜无刺激、无毒性、安全可靠 Staphylococcus aureus and Escherichia coli mixed infection, and Neisseria gonorrhoeae infection of two types of vaginitis, vaginal congestion, edema, bleeding as an indicator to observe the degree of bacterial damage to the mucosa. The curative effect of three dose groups of compound ciprofloxacin suppository (CCIPS) was investigated. The results showed that there was a significant difference between the high-dose group and the positive control group in the two model group administration experiments at the same time Vaginal mucosal irritation test, acute toxicity test shows that the drug is non-irritating, non-toxic and safe to vaginal mucosa in rats