论文部分内容阅读
采用 1∶1配比病例对照研究方法 ,对 10 5对缺血性脑卒中病人和非脑卒中的对照组病人 ,进行了血清脂蛋白 (a)、总胆固醇、甘油三脂、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的检测和分析 ,以评价它们与缺血性脑卒中的关系。结果显示 :病例组血清脂蛋白 (a)平均值为2 38.37mg/L ,明显高于对照组的 149.98mg/L ,t=3.97,P <0 .0 0 1,不同年龄组的比较中 ,只有 70岁以上年龄组血清脂蛋白 (a)明显高于 50岁以下年龄组 ,而性别在病例组内或对照组内均无显著性差异 ,将血清脂蛋白 (a)按不同等级进行分析 ,发现随着血清脂蛋白 (a)水平升高 ,缺血性脑卒中的危险性逐渐增加 ,有明显的剂量效应关系 ,多因素logistic回归分析表明 ,血清脂蛋白 (a)为缺血性脑卒中的独立危险因素 ,OR =1.93,其他危险因素还包括甘油三脂 ,而高密度脂蛋白胆固醇是缺血性脑卒中的保护因素 ,OR =0 .32。
A 1: 1 matched case-control study was conducted in 105 patients with ischemic stroke and non-stroke control subjects. Serum lipoprotein (a), total cholesterol, triglyceride, high density lipoprotein Cholesterol and low density lipoprotein cholesterol were measured and analyzed to assess their association with ischemic stroke. The results showed that the mean serum lipoprotein (a) in case group was 238.37mg / L, which was significantly higher than 149.98mg / L in control group, t = 3.97, P <0.01. In the comparison of different age groups, Only serum lipoprotein (a) in age group over 70 years old was significantly higher than those under 50 years old, and sex in the case group or control group had no significant difference. Serum lipoprotein (a) was analyzed by different grades, It was found that as the level of serum lipoprotein (a) increased, the risk of ischemic stroke gradually increased with a significant dose-response relationship. Multivariate logistic regression analysis showed that serum lipoprotein (a) was ischemic stroke OR = 1.93. Other risk factors include triglyceride, while HDL cholesterol is the protective factor of ischemic stroke, OR = 0.32.