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目的：探讨新的药物治疗脑缺血再灌注损伤。方法：用人工合成 Ｅ－选择素 ２ｍｇ·ｋｇ－１或 １０ ｍｇ·ｋｇ－１溶解于生理盐水中，静脉注入自发性高血压大鼠永久左侧大脑中动脉／颈总动脉（ＭＣＡ／ＣＣＡ）闭塞或ＭＣＡ／ＣＣＡ闭塞２ｈ后ＣＣＡ再灌注模型中。２４ｈ后，脑梗死体积用计算机扫描计算。结果：在永久性ＭＣＡ／ＣＣＡ闭死组中脑梗死体积没有差别，在ＭＣＡ／ＣＣＡ闭死后ＣＣＡ再灌注组中脑梗死体积有意义地缩小（Ｐ＜０．０１）。结论：Ｅ－选择素能够有效地减少大鼠脑缺血再灌注损伤。
Objective: To explore the new drug treatment of cerebral ischemia-reperfusion injury. Methods: The left middle cerebral artery / common carotid artery (MCA / CCA) in spontaneously hypertensive rats were intravenously injected with synthetic E-selectin 2 mg · kg-1 or 10 mg · kg- Occlusion or MCA / CCA occlusion 2h after CCA reperfusion model. After 24 hours, the volume of cerebral infarction was calculated by computer scan. RESULTS: There was no difference in infarct volume in the permanent MCA / CCA occlusion group, and the infarct volume in the CCA reperfusion group was significantly reduced (P <0.01) after MCA / CCA occlusion. Conclusion: E-selectin can effectively reduce the cerebral ischemia-reperfusion injury in rats.