有机催化不对称合成反应是目前国内外研究最为活跃的领域之一。不对称[4+2]环加成(Diels-Alder)反应是合成光学活性环状化合物的有效手段,目前报道的催化不对称Diels-Alder反应的有机催化剂主要有手性咪唑啉酮、手性Brφnsted酸、手性伯胺、金鸡纳碱衍生物等。本文对各类有机催化剂在有机催化不对称Diels-Alder反应中的应用研究进展,以及不对称诱导反应的机理进行了评述。 Organic catalytic asymmetric synthesis reaction is currently one of the most active areas of research at home and abroad. Asymmetric [4 + 2] Diels-Alder reaction is an effective method to synthesize optically active cyclic compounds. The currently reported organic catalysts for asymmetric Diels-Alder reaction are mainly chiral imidazolidinones, chiral Brφnsted acid, chiral primary amine, cinchona derivatives. In this paper, the application progress of various types of organic catalysts in the asymmetric Diels-Alder reaction of organic catalysis and the mechanism of asymmetric induced reactions are reviewed.