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目的了解韶关市健康人群埃可病毒30型(ECHO30)的中和抗体水平。方法采用中和抗体法检测流行区与非流行区人群ECHO30中和抗体,并将两区人群的检测结果进行比较。结果流行区人群ECHO30中和抗体阳性率、几何平均滴度、高滴度者所占比例分别为99.27%、(97.53±0.65)、66.78%,均高于非流行区的97.94%、(48.61±0.65)、55.15%,除中和抗体阳性率外,其余两项差异有统计学意义(t=-5.02,P=0.000;χ2=6.61,P=0.010)。流行区不同年龄人群几何平均滴度以5岁内婴幼儿最高,且随年龄增长呈下降趋势(F=3.660,P=0.006)。非流行区人群ECHO30中和抗体阳性率、几何平均滴度均以5岁内婴幼儿最低,但年龄组间差异均无统计学意义(χ2=8.38,P=0.079;F=1.344,P=0.255)。结论流行区发生的病毒性脑炎暴发是由ECHO30所致,人群ECHO30感染普遍,小于5岁的婴幼儿易感,应加强监测工作。
Objective To understand the neutralizing antibody level of ECHO30 in healthy population of Shaoguan City. Methods Neutralizing antibody method was used to detect the neutralizing antibodies against ECHO30 in endemic areas and non-endemic areas. The results of two groups were compared. Results The positive rate of ECHO30 neutralizing antibody, the geometric mean titer and the high titer were 99.27%, 97.53 ± 0.65 and 66.78% respectively in epidemic area, which were higher than 97.94% in non-endemic area (48.61 ± 0.65) and 55.15%, respectively. There were significant differences between the two groups (t = -5.02, P = 0.000; χ2 = 6.61, P = 0.010) except for the positive rate of neutralizing antibody. The geometric mean titers of people of different age groups in endemic areas were highest in infants and young children aged 5 years and decreased with age (F = 3.660, P = 0.006). The positive rate and geometric mean titer of neutralizing antibody of ECHO30 in non-endemic areas were the lowest in infants aged 5 years, but there was no significant difference between age groups (χ2 = 8.38, P = 0.079; F = 1.344, P = 0.255 ). Conclusions The outbreak of viral encephalitis in endemic areas is caused by ECHO30. ECHO30 infection in the population is common. Infants and young children less than 5 years old are susceptible. Monitoring work should be strengthened.