AIM:To determine whether or not a low dose of HB vaccinecan be effectively used in the rapid vaccination.METHODS:Rapid vaccination (0,1,2 months) with lowdose (5 μg) or routine dose (10 μg) HB vaccine was studiedin 250 subjects (130 school children and 120 universitystudents).Serum from all the participants was tested forHBsAg,anti-HBs and anti-HBc at 1,3 and 7 months afterthe first dose of vaccination and all subjects were serumHBV marks negative before the vaccination.Non-respondersto a complete initial vaccination from university studentswere given an additional vaccination with 10 μg of HBvaccine and their serum anti-HBs was tested again onemonth later.RESULTS:One month after the third dose of vaccination(third month) sero-conversion rates and geometric meantiter (GMTs) were significantly (P<0.01) higher in the routinedose (resp.89% and 106.8) than in the low dose group(resp.72% and 59.5).Sero-conversion rates and GMTswere maintained stable for another 4 months in both groups.After an additional vaccination to non-responders with 10 μgHB vaccine,17/23 subjects (13/15 from those vaccinatedwith 5 μg vaccine and 4/8 from those vaccinated with 10 μgvaccine) became anti-HBs positive,yielding similar sero-conversion rates for both dose groups.CONCLUSION:Higher sero-conversion rates and GMTswere reached in those vaccinated with 10 μg HB vaccinethan in those vaccinated with 5 μg HB vaccine after acomplete vaccination with a 0,1,2 month scheme.But thesubjects vaccinated with 5 μg vaccine can also reach thesimilar sero-conversion rate after an additional vaccination. AIM: To determine whether or not a low dose of HB vaccinecan be effectively used in the rapid vaccination. METHODS: Rapid vaccination (0,1,2 months) with lowdose (5 μg) or routine dose (10 μg) HB vaccine was studiedin 250 subjects (130 school children and 120 university students) .Serum all all the participants was tested for HBsAg, anti-HBs and anti-HBc at 1,3 and 7 months afterthe first dose of vaccination and all subjects were serum HBV marks negative before the vaccination. Non-responders to a complete initial vaccination from university students were given an additional vaccination with 10 μg of HBvaccine and their serum anti-HBs was tested again one month later .RESULTS: One month after the third dose of vaccination (third month) sero-conversion rates and Rates of GMTs were significantly (P <0.01) higher in the routine dose (resp.89% and 106.8) than in the low dose group (resp.72% and 59.5) .Sero-conversion rates and GMTswere maintained stable for another 4 months in both groups .Af ter an additional vaccination to non-responders with 10 μg HB vaccine, 17 of 23 subjects (13/15 from those vaccinated with 5 μg vaccine and 4/8 from those vaccinated with 10 μgvaccine) became anti-HBs positive, yielding similar sero-conversion rates for both dose groups. CONCLUSION: Higher sero-conversion rates and GMTswere reached in those vaccinated with 10 μg HB vaccinethan in those vaccinated with 5 μg HB vaccine after acomplete vaccination with a 0,1,2 month scheme. The theubjects vaccinated with 5 μg vaccine can also reach thesimilar sero-conversion rate after an additional vaccination