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Objective:To investigate the antidiabetic effect of aqueous extract of Merremia Iridentala (M.tridentala) root(MTRAE) in normal,glucose-loaded hyperglycemic and streptozotoein(STZ)induced diabetic rats.Methods:Oral administration of MTRAE at the doses of 50,100 and 150 nig/kg was studied in normal,glucose-loaded and STZ-diabetie rats.The three doses caused significant reduction in blood glucose levels in all the models.Results:The effect was more pronounced in 100 and 150 mg/kg than 50 mg/kg.MTRAK also showed significaut increase in serum insulin,body weight and glycogen content in liver and skeletal muscle of STZ-induced dialietie rats while there was significant reduction in the levels of serum triglyceride and total cholesterol.MTRAE also showed significant antilipidperoxidative effect in the pancreas of STZinduced diabetic rats.The antidiabetic effect of M.tridentata was compared with glibenclamide. a well known hypoglycemic drug.Conclusions:The results indicate that aqueous extract of M. tridentata root possesses significant antidiabetic activity.
Objective: To investigate the antidiabetic effect of aqueous extract of Merremia Iridentala (M. tridentala) root (MTRAE) in normal, glucose-loaded hyperglycemic and streptozotoein (STZ) induced diabetic rats. Methods: Oral administration of MTRAE at the doses of 50,100 and 150 nig / kg was studied in normal, glucose-loaded and STZ-diabetie rats. These three doses caused significant reduction in blood glucose levels in all the models. Results: The effect was more pronounced in 100 and 150 mg / kg than 50 mg /kg.MTRAK also showed significant autingest in serum insulin, body weight and glycogen content in liver and skeletal muscle of STZ-induced dialietie rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. MTRAE also showed significant antilipidroxidative effect in the pancreas of STZinduced diabetic rats. the antidiabetic effect of M.tridentata was compared with glibenclamide. a well known hypoglycemic drug. Conclusions: The results indicate that aqueous extrac t of M. tridentata root possesses significant antidiabetic activity.