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目的探讨联合检测C反应蛋白、同型半胱氨酸、D-二聚体在急性脑梗死诊断中的临床价值。方法选取中医医院脑病科住院的100例脑梗死患者,100例健康体检者为对照,应用免疫透射比浊法、酶循环法、免疫比浊法分别测定两组对象的CRP、Hcy、D-二聚体的水平,并进行对比。结果脑梗死组CRP、Hcy、D-二聚体的水平均显著高于健康对照组,差异有统计学意义(P<0.05);急性脑梗死患者血清CRP、Hcy、D-二聚体的血清及血浆浓度值随病情的严重程度而有所不同,重症患者明显高于轻型患者,并显著高于健康对照者,且差异均有统计学意义(P<0.05)。结论 CRP、Hcy、D-二聚体的水平在急性脑梗死时明显升高,为脑梗死的诊断、了解病情变化及预后提供重要的参考价值。
Objective To investigate the clinical value of combined detection of C-reactive protein, homocysteine and D-dimer in the diagnosis of acute cerebral infarction. Methods 100 cerebral infarction patients and 100 healthy volunteers who were hospitalized in the Department of Neurology of Chinese Medicine Hospital were selected as controls. The levels of CRP, Hcy and D-2 in the two groups were determined by immunoturbidimetric assay, enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry The level of polymer, and compared. Results The levels of CRP, Hcy and D-dimer in cerebral infarction group were significantly higher than those in healthy control group (P <0.05). Serum levels of CRP, Hcy and D-dimer in patients with acute cerebral infarction And plasma concentration were different according to the severity of the disease. Patients with severe disease were significantly higher than those with mild disease and were significantly higher than those with healthy controls (P <0.05). Conclusion The levels of CRP, Hcy and D-dimer are significantly increased in acute cerebral infarction, which provides an important reference value for the diagnosis of cerebral infarction and the understanding of the changes of disease and prognosis.