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目的：研究肝癌二级预防的价值。方法：1993年1月至1997年12月，将18816名肝癌高危对象随机分为筛查组与对照组。筛查组每6个月作一次AFP与实时超声检查，5年中共检出86例肝癌，对照组不作主动检查，5年中共发生51例肝癌。结果：筛查组检出之肝癌中Ⅰ期肝癌占60．5％，能作手术切除者占46．5％，5年生存率达52．7％，对照组则分别为0、7．8％与0，差异十分显著（P＜0.01）。筛查检出之病例作手术切除者术后1～5年生存率为89．7％、89.7％、84．9％、84．9％及84．9％，而非手术治疗者治疗后分别为39．8％、30.2％、19．2％、19.2％及19,2％。两者差异十分显著（P＜0．01）。与对照组相比前者差异显著，后者差异不显著。结论：筛查检出之病例应尽可能争取作手术切除才能体现肝癌二级预防之价值。
Objective: To study the value of secondary prevention of liver cancer. Methods: From January 1993 to December 1997, 18816 high-risk liver cancer patients were randomly divided into screening group and control group. The screening group performed AFP and real-time ultrasonography every 6 months. In the 5 years, 86 cases of liver cancer were detected in the Chinese Communist Party. The control group did not perform active examination. In the 5 years, 51 cases of liver cancer occurred in the Chinese Communist Party. Results: 60.5% of patients with stage I hepatocellular carcinoma were detected in the screening group, 46.5% were able to undergo surgical resection, and the 5-year survival rate was 52.7%. The control group had 0, 7.8, respectively. The difference between % and 0 is very significant (P<0.01). The 1- to 5-year survival rates of patients who were screened for surgical resection were 89.7%, 89.7%, 84.9%, 84.9%, and 84.9%, respectively, after non-surgical treatment. It was 39.8%, 30.2%, 19.2%, 19.2%, and 19,2%. The difference between the two is very significant (P <0.01). The former was significantly different from the control group, while the latter was not significantly different. Conclusion: Screening and detection of cases should strive for surgical resection as much as possible to reflect the value of secondary prevention of liver cancer.