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目的探讨β1-肾上腺素能受体(β1-AR)Arg389G ly多态性及与职业社会心理因素的交互作用对原发性高血压的影响。方法采用以职业紧张高暴露的男性列车行车人群为基础的1∶1配对病例对照研究(115对),通过问卷调查职业紧张、焦虑、抑郁、A型行为等职业社会心理因素及高血压的常见危险因素,应用PCR-RFLP技术检测β1-AR Arg389G ly多态性,通过多因素Logistic回归模型方法进行基因-环境的交互作用危险性分析。结果携带(Arg/G ly+G ly/G ly)基因型者与Arg/Arg基因型相比,其调整后OR达1.351;A型行为、特质焦虑、高“紧张反应”与Arg389G ly易感基因型同时存在的调整后OR分别达8.120、5.627和2.733。结论β1-AR Arg 389G ly可能是EH的遗传易感因素,但不是本研究人群EH的主要危险因素;职业社会心理因素与β1-AR Arg389G ly遗传因素间的环境-基因交互作用可能在EH的发病中发挥重要作用,且与职业人群的职业特点及个性、情绪因素密切相关。
Objective To investigate the effects of β1-adrenoceptor (β1-AR) Arg389Gli polymorphism and its interaction with occupational psychosocial factors on essential hypertension. Methods One-to-one matched case-control study (115 pairs) based on the male trains exposed by high occupational stress was used to investigate occupational social psychological factors such as occupational stress, anxiety, depression and type A behaviors, as well as the prevalence of hypertension Risk factors, PCR-RFLP detection of β1-AR Arg389G ly polymorphism, multivariate Logistic regression model for gene-environment interaction risk analysis. Results Compared with the Arg / Arg genotype, the OR of the Arg / G ly + G ly / G ly genotype was 1.351. The A type behavior, trait anxiety, high stress response and Arg389G ly Adjusted OR of co-existing susceptible genotypes were 8.120, 5.627 and 2.733 respectively. CONCLUSIONS: β1-AR Arg 389G ly may be a predisposing factor for EH but not a major risk factor for EH in this population. The environmental-gene interaction between occupational social psychological factors and β1-AR Arg389G ly genetic factors may be related to EH Play an important role in the pathogenesis, and occupational characteristics of the professional population and personality, emotional factors are closely related.