氨甲喋吟(以下简称MTX)是抗叶酸药,它影响细胞周期的S期,使肿瘤细胞不能增殖。以往主要联合用于儿童急性白血病的诱导缓解后维持治疗,随着临床用药的研究,发现MTX在恶性滋养细胞肿瘤的化疗史上有突破性进展,且可用于早期输卵管妊娠的保守治疗。其用药途径颇多,疗效满意。本文试就其作用机制、临床用途、用药方法及适应症加以综述。 Methotrexate (MTX) is an anti-folate drug that affects the S phase of the cell cycle and prevents tumor cells from proliferating. In the past the main combination for the treatment of acute leukemia in patients with remission maintenance treatment, with the clinical study found that MTX in malignant trophoblastic tumor chemotherapy history of breakthrough, and can be used for conservative treatment of early tubal pregnancy. A lot of its use of drugs, effective satisfaction. This article tries to review its mechanism of action, clinical use, methods of treatment and indications.