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近年来,以α_1-m作为肾小管重吸收功能的指标已愈来愈受到国内外的重视。我们采用放射免疫分析法测定尿α_1-m,观察了80例临床使用丁胺卡那霉素治疗的患儿并与正常小儿组作比较,以探讨作为临床应用较广泛的抗生素对患儿肾脏的毒性作用,现将结果报道如下。 对象和方法 一、对象:选自我院1995年～1996年儿科收治的一般上、下呼吸道感染的患儿80例(男46,女34),其中上呼吸道感染者35例,下呼吸道感染者45例。均无其他脏器功能损害,无肾炎史,尿常规检查正常。年龄分别为:6月～1岁20例;1～2岁25例;2～8岁35例。入院后使用丁胺卡那霉素10mg/kg,每日一次。分别于用药三天以上检测尿α_1-m,同时检查尿常规。对照组选自本院及本矿务局机关幼儿园经体检各项指标正常的健康儿童40例(男22,女18),年龄1～7岁之间。年龄、性别经统计学处理无显著差异(p>0.05)。 二、方法:用一次性清洁尿杯收集患儿随意尿
In recent years, α_1-m as an indicator of renal tubular reabsorption has been more and more attention at home and abroad. We measured urinary α_1-m by radioimmunoassay, observed 80 cases of children treated with amikacin clinically and compared with normal children to explore the clinical application of a wider range of antibiotics in children with renal Toxic effects, the results are reported below. Subjects and Methods I. Object: 80 children (46 males and 34 females) with general upper respiratory tract infection and lower respiratory tract infection selected from our hospital from 1995 to 1996 were enrolled. Among them, 35 were upper respiratory tract infection and 45 were lower respiratory tract infection example. No other organ dysfunction, no history of nephritis, urine routine examination was normal. The ages were from June to 1 year old in 20 cases, 1 to 2 years old in 25 cases and 2 to 8 years old in 35 cases. After admission, amikacin 10mg / kg, once daily. Urine were tested for more than three days urine α_1-m, urine tests at the same time. The control group was selected from 40 hospitalized healthy children (22 males and 18 females) with normal indexes of various physical examinations in our hospital and the Kindergarten of the Bureau of Mines, aged 1 to 7 years old. Age, sex, no significant difference by statistical analysis (p> 0.05). Second, methods: disposable urinal cups with free urine collection