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经济合作与发展组织(Organization for Economic Co-operation and Development,OECD)推荐的啮齿类动物28天重复剂量经口毒性试验(OECD TG 407)是一种广泛用于评价化学物一般毒性的毒理学试验方案。OECD在1998年对其进行改良后,建立TG 407改良试验并经世界多国实验室验证,用于检测化学物的内分泌干扰作用。本文简要介绍了OECD TG 407改良试验指南,并对其进展情况以及优缺点进行综述,以期为我国的内分泌干扰物的评价体系提供参考。
The 28-day repeated dose oral toxicity test (OECD TG 407) recommended by the Organization for Economic Co-operation and Development (OECD) for rodents is a toxicology test widely used to assess the general toxicity of chemicals Program. OECD in 1998 after its improvement, the establishment of TG 407 modified test and verified by the world multinational laboratories, for the detection of chemical endocrine disrupting effect. This article briefly introduced the OECD TG 407 improved test guidelines, and its progress and advantages and disadvantages are reviewed, with a view to China’s endocrine disruptors evaluation system to provide a reference.