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自一九七二年Melmon发现白细胞表面具有组胺受体,人们就开始重视该受体与机体免疫的关系。十余年的研究证明,组胺受体在T细胞各亚群的不同分布,表现出免疫负反馈调节效应,淋巴细胞组胺受体的变化调节机体的组咆免疫和体液免疫反应;在一些免疫性疾病中存在淋巴细胞组胺受体的异常。为了深入认识淋巴细胞组胺受体在免疫调节中的作用,寻求可靠易行的检测方法,理解在免疫性疾病中淋巴细胞组胺受体变化情况及其诊断意义,本文拟就淋巴细胞组胺受体的功能、检测方法及其在免疫性疾病中的表现加以综述。一淋巴细胞组胺受体的功能 (一) 诱导抑制性细胞活性免疫反应如同其他复杂的生物过程由一系列正的和负的调节因素所控制。大部分的
Since 1972, Melmon found that histamine receptors on the surface of leukocytes, people began to attach importance to the relationship between the receptor and immune. More than ten years of research have shown that histamine receptors in different distribution of T cell subsets, showing immune negative feedback regulation effect, changes in lymphocyte histamine receptors regulate the body roar and humoral immune response; in some There are abnormalities of lymphocyte histamine receptors in immune diseases. In order to understand the role of lymphocyte histamine receptors in immune regulation, to seek reliable and easy detection methods to understand the changes of lymphocyte histamine receptors in immunological diseases and its diagnostic significance, this article intends to lymphocyte histamine Receptor function, detection methods and their performance in immune diseases are reviewed. The function of a lymphocyte histamine receptor (A) induces inhibitory cell activity Immune response is controlled by a series of positive and negative regulators as other complex biological processes. Most of the