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紫红獐牙菜提取物是一种应用广泛的中国传统中药,其抗乙型肝炎病毒,保肝,降低血糖等作用已经被报道。在本研究中,我们发现紫红獐牙菜酮提取物可以改善1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的帕金森(PD)小鼠的运动功能障碍。此外,我们还发现该提取物能够提高纹状体中多巴胺(DA)和高香草酸(HVA)的含量,缓解由于MPTP导致的黑质致密区的酪氨酸羟化酶(TH)阳性神经元的缺失。这些结果表明,紫红獐牙菜酮提取物具有对抗MPTP神经毒素的神经保护作用,有望成为一个潜在的治疗帕金森病的药物。
Purple Swertia extract is a widely used traditional Chinese medicine, its anti-hepatitis B virus, liver, reduce blood sugar and other effects have been reported. In the present study, we found that purplish mussel ketone extract can improve the inhibitory effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced Parkinson’s Motor dysfunction. In addition, we also found that the extract increased the content of dopamine (DA) and homovanillic acid (HVA) in the striatum and relieved tyrosine hydroxylase (TH) positive neurons due to MPTP-induced substantia nigra compactness The lack of. These results indicate that purplish mussel extract has the neuroprotective effect against MPTP neurotoxin and is expected to become a potential drug for the treatment of Parkinson’s disease.