目前研究HDL抑制粥样斑块的机理是防治动脉粥样硬化病的一个重要课题。我们在利用树鼩建立粥样斑块模型中发现,树鼩具有很高的血清α脂蛋白(占总脂蛋白60～75％),用高于家兔4～5倍高胆固醇长期摄入,仍不形成典型的粥样病变。实验先后进行了二次,历时3年。第一次实验有22只树鼩,雌雄各半,分2组。实验组12只,平均体重130.5±11.2克,每周喂6次胆固醇饲料(胆固醇0.2克、蛋黄 The current study of HDL inhibition of atherosclerotic plaque mechanism is an important issue prevention and treatment of atherosclerosis. We found in the use of tree shrews plaque model found in the tree shrews have a high serum α-lipoprotein (total lipoprotein 60 to 75%), with higher than 4 to 5 times the rabbit high cholesterol intake, Still does not form a typical atherosclerosis. The experiment was carried out twice, which lasted 3 years. The first experiment has 22 trees, male and female, divided into 2 groups. Experimental group of 12, average body weight 130.5 ± 11.2 grams, 6 times a week feeding cholesterol feed (cholesterol 0.2 grams, egg yolk