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目的探讨长期口服他汀类药物与急性ST段抬高型心肌梗死(STEMI)行急诊经皮冠脉介入(PCI)治疗患者预后的关系。方法选择STEMI行急诊PCI患者301例,根据长期是否服用他汀类药物分为未服组(198例)和服用组(103例)。对患者随访1年,观察主要心脑血管不良事件(MACCE)发生率。并对各因素采用Logistic回归分析。结果未服用组MACCE发生率〔50/198(25.3%)〕显著高于服用组〔14/103(13.6%)〕(P<0.05),主要表现在再发心绞痛〔36/198(18.2%)vs.7/103(6.8%),P<0.01〕和再次住院〔40/198(20.2%)vs.9/103(8.7%),P<0.01〕。多因素Logistic回归分析示长期服用他汀类药物是一个保护因子(OR 0.24,95%CI 0.10-0.55,P<0.01)。结论长期服用他汀类药物可降低STEMI行急诊PCI患者1年MACCE的发生率,是一个保护因子。
Objective To investigate the relationship between long-term oral statins and the prognosis of acute ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Methods A total of 301 STEMI patients undergoing PCI were enrolled in this study. They were divided into two groups according to their long-term statin use: 198 cases without medication and 103 cases with medication. Patients were followed up for 1 year to observe the incidence of major cardiovascular and cerebrovascular adverse events (MACCE). Logistic regression analysis was used to analyze the factors. Results The incidence of MACCE in the untreated group (50/198, 25.3%) was significantly higher than that in the control group (14/103, 13.6%, P <0.05), mainly in recurrent angina (36/198, 18.2% vs 7/103 (6.8%), P <0.01) and hospitalized again (40/198 (20.2%) vs 9/103 (8.7%), P <0.01). Multivariate logistic regression analysis showed that long-term statin use was a protective factor (OR 0.24, 95% CI 0.10-0.55, P <0.01). Conclusion Long-term statin use reduces the incidence of MACCE by 1 year in STEMI emergency PCI patients and is a protective factor.