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为了进一步了解肿瘤从良性表型向恶性表型转化过程的分子生物学基础,我们选择大肠癌及腺瘤为研究对象,在同一组癌及腺瘤标本中,同时观察肿瘤抑制基因(RB和P53基因)、癌基因(myc和ras基因)的表达水平及基因结构的变化情况,现报道如下。
In order to further understand the molecular biological basis of tumor transformation from a benign phenotype to a malignant phenotype, we chose colorectal cancer and adenoma as the research subjects. In the same group of cancer and adenoma specimens, simultaneous observation of tumor suppressor genes (RB and P53) was performed. The expression levels of genes, oncogenes (myc and ras genes), and changes in gene structure are reported below.