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目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)3种检测指标对儿童细菌感染的诊断价值,为临床及时确诊提供有价值检测指标。方法将住院患儿分为细菌感染组(A组)、病毒感染组(B组)、同时设健康对照组(C组);静脉采血测定PCT、CRP、WBC,比较3种指标水平,分析这些指标的诊断敏感性及特异性。结果 A组PCT、CRP、WBC明显高于B组、C组(P<0.05);B组PCT、WBC与C组比较无统计学意义(P>0.05),CRP高于C组有统计学意义(P<0.05);PCT、CRP、WBC诊断细菌感染的敏感性分别为98.5%、98.8%、81.2%;特异性分别为82.8%、42.4%、68.0%。结论 PCT、CRP、WBC三项检测指标,各有优缺点,联合检测,能及早进行诊断及鉴别诊断,以指导合理使用抗菌药物,避免抗菌药物滥用,延缓细菌耐药产生。
Objective To investigate the diagnostic value of the three detection indexes of serum procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC) in children with bacterial infection and to provide valuable detection indexes for clinical diagnosis in time. Methods Inpatients were divided into bacterial infection group (A group), virus infection group (B group) and healthy control group (C group). Blood samples were collected for determination of PCT, CRP and WBC by venous blood sampling. The diagnostic sensitivity and specificity of the indicator. Results The PCT, CRP and WBC in group A were significantly higher than those in group B and group C (P <0.05). There was no significant difference in PCT, WBC and C between group B and group C (P> 0.05) (P <0.05). The sensitivity of PCT, CRP and WBC in diagnosis of bacterial infection were 98.5%, 98.8% and 81.2% respectively, and the specificity were 82.8%, 42.4% and 68.0% respectively. Conclusion The three indexes of PCT, CRP and WBC have their own advantages and disadvantages, and their combined detection can diagnose and differentiate as soon as possible so as to guide the rational use of antimicrobial agents, avoid the abuse of antimicrobial agents and delay the emergence of bacterial resistance.