Reinforced concrete(RC) buildings in Nepal are constructed with RC frames and masonry infill panels. These structures exhibit a highly non-linear inelastic behavior resulting from the interaction between the panels and frames. This paper presents an extensive case study of existing RC buildings in Nepal. Non-linear analyses were performed on structural models of the buildings considered as a bare frame and with masonry infill, in order to evaluate the influence of infill walls on the failure mechanisms. Five three-storey buildings with different structural configurations and detailing were selected. The effect of masonry infill panels on structural response was delineated by comparing the bare-framed response with the infill response. Seismic performance is evaluated with regard to global strength, stiffness, energy dissipation, inter-storey drift, and total deflection of the structure. A parametric analysis of structures with masonry infill is also performed. For this, the influence of different material properties is studied, namely diagonal compressive stress, modulus of elasticity and tensile stress of masonry infill panels. Study results show that masonry infill increases the global strength and stiffness of the structures; it decreases the inter-storey drift and hence the total displacement of the structure. The results quantify the influence of the infill panels on structural response and, in particular, the effect of the diagonal compressive strength of the masonry wall. Reinforced concrete (RC) buildings in Nepal are constructed with RC frames and masonry infill panels. These structures exhibit a highly non-linear inelastic behavior resulting from the interaction between the panels and frames. This paper presents an extensive case study of existing RC buildings in Nepal. Non-linear analyzes were performed on structural models of the buildings considered as a bare frame and with masonry infill, in order to evaluate the influence of infill walls on the failure mechanisms. Five three-storey buildings with different structural configurations and detailing were selected. The effect of masonry infill panels on structural response was delineated by comparing the bare-framed response with the infill response. structure. A parametric analysis of structures with masonry infill is also performed. For this, the influence o study results show that masonry infill increases the global strength and stiffness of the structures; it decreases the inter-storey drift and hence the total displacement of the structure. The results quantify the influence of the infill panels on structural response and, in particular, the effect of the diagonal compressive strength of the masonry wall.