论文部分内容阅读
为探讨环境温度与高原肺水肿的关系,本实验采用~(51)Cr标记红血球的方法,观察了温度和缺氧对大白鼠肺血管外含水量的影响。结果表明,动物于10℃模拟6000m高原持续48小时,肺血量减少,肺血管外含水量略有升高,但无统计学意义(P>0.05)。当环境温度下降至5、0和-5℃时,肺血量和肺血管外含水量均逐渐升高,且肺血管外含水量明显高于对照值(P<0.05和P<0.01)。寒冷缺氧使肺血管外含水量增加的机制,可能与血液自外周血管向肺循环转移和肺静脉收缩等因素有关。这些因素可使缺氧后的肺动脉高压进一步升高,促进肺水肿发生。
In order to explore the relationship between ambient temperature and altitude pulmonary edema, we used ~ (51) Cr labeled red blood cells to observe the effects of temperature and hypoxia on pulmonary extravascular water content in rats. The results showed that the animals underwent a simulated 6000m plateau at 10 ℃ for 48 hours, the pulmonary blood volume decreased, and the extravascular pulmonary water content slightly increased (P> 0.05). When the ambient temperature dropped to 5, 0 and -5 ℃, the pulmonary blood volume and extra-pulmonary extravascular water volume gradually increased, and extra-pulmonary vascular water content was significantly higher than the control (P <0.05 and P <0.01). Cold hypoxia so that increased pulmonary extravascular water volume may be related to the blood from the peripheral blood vessels to the pulmonary circulation and pulmonary vein contraction and other factors. These factors can make pulmonary hypertension after hypoxia to further increase, promote pulmonary edema.