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目的:探讨溃疡性结肠炎(UC)患者血浆FPA、F1+2、AT-Ⅲ的变化及相关性。方法:采用ELISA法检测30例活动期UC患者、20缓解期UC患者及20例对照者的血浆纤维蛋白肽A(FPA)、凝血酶原片段1+2(F1+2)、抗凝血酶-Ⅲ(AT-Ⅲ)水平。结果:血浆FPA、F1+2水平活动期UC高于缓解期UC及对照组、缓解期UC高于对照组;AT-Ⅲ水平活动期UC低于缓解期UC及对照组、缓解期UC低于对照组,各组比较差别有统计学意义(P<0.01);活动期UC患者随着疾病严重度加重及病变范围扩大,血浆FPA、F1+2水平升高(P<0.05)、血浆AT-Ⅲ水平下降,差别有统计学意义(P<0.01);FPA与AT-Ⅲ、F1+2与AT-Ⅲ的变化存在负相关(P<0.05)。结论:UC患者处于明显的血栓前状态,FPA、F1+2、AT-Ⅲ水平的变化与疾病活动性、疾病严重程度及病变累及范围有关。
Objective: To investigate the changes and correlations of plasma FPA, F1 + 2 and AT-Ⅲ in patients with ulcerative colitis (UC). Methods: The plasma levels of fibrinolipopeptide A (FPA), prothrombin fragment 1 + 2 (F1 + 2), antithrombin in 30 active UC patients, 20 remission UC patients and 20 healthy controls were measured by ELISA. -Ⅲ (AT-Ⅲ) levels. Results: The levels of plasma FPA and F1 + 2 in active stage UC were higher than those in remission stage UC and control group, while UC in remission stage was higher than that in control group. UC in AT-Ⅲ level was lower than that in remission stage UC and control group, The levels of FPA and F1 + 2 in plasma of patients with active UC increased (P <0.01), and the levels of plasma FPA and F1 + 2 increased with the severity of disease and the extent of disease in active UC patients (P <0.01) (P <0.01). There was a negative correlation between FPA and AT-Ⅲ, F1 + 2 and AT-Ⅲ (P <0.05). Conclusions: The pre-thrombotic state of UC patients is obvious. The changes of FPA, F1 + 2 and AT-Ⅲ levels are related to disease activity, disease severity and extent of lesion involvement.