目的探讨POEMS综合征的临床特点,以便在疾病早期认识该综合征。方法回顾总结笔者诊治的POEMS综合征患者的临床特点,并结合文献进行分析。结果POEMS综合征患者首发症状多为周围神经病,但常合并其他器官受累,病程长,病情进展慢,易反复,临床经过不符合一般周围神经病特点,预后较差。结论早期加强对拟诊周围神经病患者的躯体全面检查,常规进行血清蛋白电泳和骨骼X线检查,可以降低该疾病的漏诊及误诊。 Objective To investigate the clinical features of POEMS syndrome in order to recognize the syndrome early in the disease. Methods To review and summarize the clinical features of POEMS syndrome patients treated by the author and analyze them with the literature. Results The first symptom of POEMS syndrome was mostly peripheral neuropathy, but it was often associated with other organs involved. The course of disease was long and the disease progressed slowly and easily. The clinical symptoms of POEMS syndrome were not consistent with the features of general peripheral neuropathy and the prognosis was poor. CONCLUSIONS: Early comprehensive physical examinations of somatic peripheral neuropathy in patients with suspected peripheral neuropathy and routine serum protein electrophoresis and skeletal X-ray examination may reduce the missed diagnosis and misdiagnosis of the disease.