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目的：探讨并比较急性牙髓炎和牙齿开髓刺激后不同时间点，三叉神经脊束核尾侧亚核（Ｖｃ）内兴奋神经元的分布。方法：分别制备大鼠急性牙髓炎和牙齿开髓模型，应用免疫组织化学染色方法观察大鼠牙齿开髓后１、２、４ｈ 和急性牙髓炎２ 、４ｈ 组Ｖｃ 内Ｆｏｓ 免疫阳性神经元的分布。结果：开髓各组Ｆｏｓ 免疫阳性神经元集中分布在Ｖｃ 浅层背侧区；急性牙髓炎２ｈ 组，主要分布在Ｖｃ 浅层背侧区；４ｈ 组，Ｖｃ 各层内可见Ｆｏｓ 免疫阳性神经元的分布。结论：牙齿次机械损伤和炎症刺激可以兴奋Ｖｃ 内不同区域的神经元，牙髓炎组Ｖｃ 内神经元兴奋有时间上的相继性。
OBJECTIVE: To investigate and compare the distribution of excitatory neurons in the subnucleus caudalis (Vc) at different time points after acute pulpitis and dental pulp stimulation. Methods: Acute pulpitis and open pulp models were prepared respectively. Immunohistochemical staining was used to observe Fos immunoreactive neurons in Vc at 1, 2, 4 h and 2, 4 h after open dental pulp in rats Distribution. Results: Fos immunoreactive neurons in each group were mainly distributed in the dorsal Vc region. In the acute pulpitis group 2h, they were mainly distributed in the dorsal region of Vc. Fos immunoreactive nerve The distribution of yuan. CONCLUSION: Tooth secondary mechanical injury and inflammatory stimuli can excite the neurons in different regions of Vc. Neurons in Vc of pulpitis group have the temporal succession.