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在胸腺呈病理性萎缩的321例尸检病例中,有77例(24％)呈重度病理性萎缩,HE切片中,主要表现为淋巴细胞重度减少、小叶支架结构塌陷及小叶间隔明显纤维化。抗角蛋白免疫组化染色反应(PAP法),显示有多量密集的阳性反应细胞(网状上皮细胞)。34例20岁以上生理性退化的胸腺抗角蛋白免疫组化反应,仅见微量阳性反应细胞,胸腺小体数目减少比病理性萎缩多见,提示胸腺病理性萎缩与生理性退化的组织学变化差异明显。
Of the 321 autopsy cases with pathological atrophy in the thymus, 77 (24%) showed severe pathological atrophy. In HE sections, there were mainly severe reduction of lymphocytes, collapsed lobule scaffolds and significant fibrosis of interlobular septa. Anti-keratin immunohistochemical staining reaction (PAP method), showing a large number of dense positive cells (reticular epithelial cells). Thirty-four cases of physiologically degenerated thymus anti-keratin immunohistochemical reaction in 34 cases, only a small amount of positive cells, the number of thymus decreased more than the pathological atrophy more common, suggesting that thymus atrophy and physiological degeneration histological differences obvious.