丁型肝炎病毒(HDV)是有缺陷的小RNA病毒,其复制依赖于乙型肝炎表面抗原(HBsAg)的存在。慢性HDV感染常导致严重肝脏疾病,多达70％的感染者进展为肝硬化。目前慢性丁型肝炎(CHD)尚无有效的治疗,虽有研究表明,长期、大剂量α干扰素治疗可能有效,但有效率低、停药后常复发,并且α干扰素价格昂贵、耐受性差,因此慢性HDV感染的治疗受到限制。近期证实,口服拉米夫定对HBV感染有效,有鉴于此,作者 Hepatitis D virus (HDV) is a defective picornavirus whose replication depends on the presence of hepatitis B surface antigen (HBsAg). Chronic HDV infections often lead to severe liver disease and as many as 70% of those who progress to cirrhosis. At present, there is no effective treatment for CHD. Although studies have shown that long-term and high-dose interferon-alpha treatment may be effective, but its efficacy is low, relapse after drug withdrawal is frequent, and alpha interferon is expensive and tolerable Poor sex, so the treatment of chronic HDV infection is limited. Recently confirmed that oral lamivudine effective for HBV infection, in view of this, the author