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目的 :探讨血、尿 β2 微球蛋白在高血压病患者不同分级与不同危险分层中的意义。方法 :选择高血压患者 80例 ,进行分级及危险分层后 ,分别测定其血尿素氮 (血BUN)、血肌酐 (Cr)、血尿 β2 微球蛋白 (β2 MG )的浓度。分析预测肾功能损害的敏感指标。结果 :在低危级 1级高血压患者中 ,尿β2 MG检测的阳性率均最高 (P <0 0 5 )。随着血压级别的增加和危险分层的增高 ,血尿β2 MG的值比低一级或低一层患者均显著增高 (P <0 0 5 )。在 3级高血压和极高危患者中 ,才有BUN、Cr的变化。结论 :血尿 β2 MG是反映高血压病患者肾功能损害的较早期指标 ,且对于高血压病患者预后的判定有一定的临床意义
Objective: To investigate the significance of blood and urine β2-microglobulin in different grading and different risk stratification in patients with essential hypertension. Methods: Eighty hypertensive patients were selected for classification and risk stratification. The blood urea nitrogen (BUN), serum creatinine (Cr) and β2 microglobulin (β2 MG) concentrations were measured. Analysis of predictive indicators of renal damage. Results: The positive rate of urine β2 MG was the highest in low-risk grade 1 hypertensive patients (P <0.05). With the increase of blood pressure level and the increase of risk stratification, the value of β2 MG in hematuria was significantly higher than that in patients with lower level or lower level (P <0.05). In grade 3 hypertension and very high-risk patients, only BUN, Cr changes. Conclusion: Hematuria β2 MG is an early indicator of renal impairment in patients with essential hypertension, and has certain clinical significance for the determination of prognosis in patients with essential hypertension