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目的探讨质子泵抑制剂对消化性溃疡出血的疗效。方法 55例为海伦市人民医院消化内科2a来住院的消化性溃疡出血患者,均排除慢性肝病、血液病等影响凝血机制疾病患者,随机分为A、B两组,A组为治疗组(28例),B组为对照组(27例),均给予质子泵抑制剂治疗,但不同的是A组给予质子泵抑制剂首次剂量80mg,并以8mg/h维持24～48h;B组给予质子泵抑制剂40mg,2次/d。结果 A组显效17例,有效10例,无效1例,总有效率96.4%;B组显效10例,有效12例,无效5例,总有效率81.5%,两组对比P<0.05。结论质子泵抑制剂“80+8”剂量治疗消化性溃疡出血有显著疗效,未见明显不良反应。
Objective To investigate the effect of proton pump inhibitors on peptic ulcer bleeding. Methods A total of 55 patients with peptic ulcer bleeding who were hospitalized in Department of Gastroenterology, Helena People’s Hospital 2a were excluded from the patients with coagulation-related diseases, such as chronic liver diseases and hematological diseases, and were randomly divided into A and B groups. A group (Group B: control group, n = 27) were treated with proton pump inhibitor, except that the first dose of proton pump inhibitor in group A was 80 mg and maintained at 8 mg / h for 24-48 h. The group B was given proton Pump inhibitor 40mg, 2 times / d. Results In group A, 17 cases were markedly effective, 10 cases were effective, 1 case was ineffective, and the total effective rate was 96.4%. In group B, 10 cases were markedly effective, 12 cases were effective, 5 cases were ineffective and the total effective rate was 81.5%. Conclusion Proton pump inhibitor “80 +8” dose of peptic ulcer bleeding have a significant effect, no significant adverse reactions.